TIMI 8 compared the efficacy of hirulog with unfractionated heparin for the treatment among patients presenting with unstable angina and non-Q-wave myocardial infarction. MAIN RESULTS: Bivalirudin as a replacement for unfractionated heparin in unstable angina/non-ST-elevation myocardial infarction: observations from the TIMI 8 trial Am Heart J. 2002 Feb;143(2):229-34. PRESENTATIONS TIMI 8 Slides