Progressive changes in cardiac critical care have driven a need for innovation in research and clinical care. The Critical Care Cardiology Trials Network (CCCTN) is a collaborative research network drawn from national leaders in critical care cardiology and coordinated by the TIMI Study Group. Our mission is to design and execute observational studies and clinical trials that will advance the care of patients who require cardiac critical care.
Learn about the CCCTN COVID-PACT clinical trial, a multicenter, randomized, open-label, 2 x 2 factorial design trial of full-dose anticoagulation vs. standard-dose prophylactic anticoagulation and antiplatelet therapy vs. no antiplatelet therapy on the risk of venous or arterial thrombotic events in ICU patients with COVID-19. Study patients will be followed until their 28th day or hospital discharge, whichever comes first.
CCCTN MCS Shock (Berg, AHA 2019)
Temporary Mechanical Circulatory Support Use In Tertiary Cardiac Intensive Care Units Before And After The UNOS Heart Transplantation Allocation System Update: Insights From The Critical Care Cardiology Trials Network (CCCTN) Registry (Varshney, ACC 2020)
In-Hospital vs Out-of-Hospital Cardiac Arrest in Patients Presenting to Cardiac Intensive Care Units From the Critical Care Cardiology Trials Network (CCCTN) (Carnicelli, AHA 2020)
De Novo vs. Acute-on-Chronic Presentations of Heart Failure Associated Cardiogenic Shock in CICUs Data From the Critical Care Cardiology Trials Network (CCCTN) (Bhatt, ACC 2021)
Clinical Characteristics And Outcomes Of Older Patients In Cardiac Intensive Care Units- From The Critical Care Cardiology Trials Network Registry (Alviar, ACC 2021)
Multi-Marker Risk Assessment in Patients Hospitalized with COVID-19 (Bhatt, AHA 2021)
Elucidating Clinical Phenotypes of Patients with Mixed Shock Admitted to Cardiac Intensive Care Units. Insights from the Critical Care Cardiology Trial. (Dewanjee, AHA 2021)
Clinician and Algorithmic Application of the 2019 and 2022 SCAI Shock Stages in the CCCTN (Patel, ACC 2022)
Characteristics and Outcomes of Adults with Congenital Heart Disease in the CICU-Insights from the Critical Care Cardiology Trials Network (CCCTN) (Keane, ACC 2022)
Cardiac Surgical Therapy in the Contemporary CICU-Implications for the Heart Team, from CCCTN (Metkus, ACC 2022)
Targeted Proteomic Profiling of Cardiogenic Shock in the Cardiac Intensive Care Unit-An Analysis from the CCCTN (Lopes, ACC 2022) (with audio)
Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. Am Heart J. 2020 Apr;222:8-14.
Use of Temporary Mechanical Circulatory Support for Management of Cardiogenic Shock Before and After the United Network for Organ Sharing Donor Heart Allocation System Changes. JAMA Cardiol. 2020 Jun 1;5(6):703-708.
Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. JAMA Cardiol. 2019 Sep 1;4(9):928-935.
End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry. Eur Heart J Acute Cardiovasc Care. 2022 Jan 5:zuab121. doi: 10.1093/ehjacc/zuab121.
Epidemiology of Acute Heart Failure in Critically Ill Patients with COVID-19: An Analysis from the Critical Care Cardiology Trials Network. J Card Fail. 2022 Jan 17:S1071-9164(22)00007-0. doi: 10.1016/j.cardfail.2021.12.020.
A pragmatic lab-based tool for risk assessment in cardiac critical care: data from the Critical Care Cardiology Trials Network (CCCTN) Registry. Eur Heart J Acute Cardiovasc Care. 2022 Feb 3:zuac012. doi: 10.1093/ehjacc/zuac012.
Patients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry. Circ Cardiovasc Qual Outcomes. 2022 Jul 5:101161CIRCOUTCOMES121008652. doi: 10.1161/CIRCOUTCOMES.121.008652.