Critical Care Cardiology Trials Network (CCCTN)

Progressive changes in cardiac critical care have driven a need for innovation in research and clinical care. The Critical Care Cardiology Trials Network (CCCTN) is a collaborative research network drawn from national leaders in critical care cardiology and coordinated by the TIMI Study Group.  Our mission is to design and execute observational studies and clinical trials that will advance the care of patients who require cardiac critical care.

Learn about the CCCTN COVID-PACT clinical trial, a multicenter, randomized, open-label, 2 x 2 factorial design trial of full-dose anticoagulation vs. standard-dose prophylactic anticoagulation and antiplatelet therapy vs. no antiplatelet therapy on the risk of venous or arterial thrombotic events in ICU patients with COVID-19. Study patients will be followed until their 28th day or hospital discharge, whichever comes first.

PRESENTATIONS

CCCTN MCS Shock (Berg, AHA 2019)
Temporary Mechanical Circulatory Support Use In Tertiary Cardiac Intensive Care Units Before And After The UNOS Heart Transplantation Allocation System Update: Insights From The Critical Care Cardiology Trials Network (CCCTN) Registry (Varshney, ACC 2020)
In-Hospital vs Out-of-Hospital Cardiac Arrest in Patients Presenting to Cardiac Intensive Care Units From the Critical Care Cardiology Trials Network (CCCTN) (Carnicelli, AHA 2020)
De Novo vs. Acute-on-Chronic Presentations of Heart Failure Associated Cardiogenic Shock in CICUs Data From the Critical Care Cardiology Trials Network (CCCTN) (Bhatt, ACC 2021)
Clinical Characteristics And Outcomes Of Older Patients In Cardiac Intensive Care Units- From The Critical Care Cardiology Trials Network Registry (Alviar, ACC 2021)
Multi-Marker Risk Assessment in Patients Hospitalized with COVID-19 (Bhatt, AHA 2021)
Elucidating Clinical Phenotypes of Patients with Mixed Shock Admitted to Cardiac Intensive Care Units. Insights from the Critical Care Cardiology Trial. (Dewanjee, AHA 2021)

PUBLICATIONS

Advanced Respiratory Support in the Contemporary Cardiac ICU. Crit Care Explor. 2020 Sep 17;2(9):e0182.

Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. Am Heart J. 2020 Apr;222:8-14.

Use of Temporary Mechanical Circulatory Support for Management of Cardiogenic Shock Before and After the United Network for Organ Sharing Donor Heart Allocation System Changes. JAMA Cardiol. 2020 Jun 1;5(6):703-708.

Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circ Heart Fail. 2019 Nov;12(11):e006635.

Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. JAMA Cardiol. 2019 Sep 1;4(9):928-935.

Epidemiology of Shock in Contemporary Cardiac Intensive Care Units. Circ Cardiovasc Qual Outcomes. 2019 Mar;12(3):e005618.

The Range of Cardiogenic Shock Survival by Clinical Stage: Data From the Critical Care Cardiology Trials Network Registry. Crit Care Med. 2021 Aug 1;49(8):1293-1302.

Management and Outcomes of Cardiogenic Shock in Cardiac ICUs With Versus Without Shock Teams. J Am Coll Cardiol. 2021 Sep 28;78(13):1309-1317.

Closing the Gap: Insights into the Epidemiology of Heart Failure Care from the Critical Care Cardiology Trials Network. J Card Fail. 2021 Oct;27(10):1146-1147.

De Novo vs Acute-on-Chronic Presentations of Heart Failure-Related Cardiogenic Shock: Insights from the Critical Care Cardiology Trials Network Registry. J Card Fail. 2021 Oct;27(10):1073-1081.

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