3/16/23 – Congratulations to TIMI Investigator Dr. Brian Bergmark, who has been promoted to Assistant Professor of Medicine at Harvard Medical School!

3/3/23 – The TIMI Study Group podcast, TIMI Talks, launched today on all major podcast platforms and our website!

2/22/23 – TIMI Study Group will host a brand new podcast, TIMI Talks, starting in March of 2023!  TIMI Talks will bring you the latest info on new clinical trials, TIMI publications, and feature roundtable discussions with the experts.  We’ll cover cardiology meeting recaps, journal clubs, statistical discussions and more.  See the trailer below and stay tuned!

7/21/22 – Dr. Michelle O’Donoghue has been appointed as the inaugural incumbent of the McGillycuddy-Logue Distinguished Chair in Cardiology at Brigham and Women’s Hospital. This Chair was established to promote women’s cardiovascular health and to support women faculty in cardiovascular medicine at Brigham and Women’s Hospital.  Congratulations!

5/13/22 – Congratulations to Dr. Stephen Wiviott on his promotion to Professor of Medicine at Harvard Medical School!

6/1/21JACC Focus Seminar on the TIMI Study Group by Drs. Sabatine & Braunwald now available online at JACC.  Read about the origin, practice-changing trials over the past 3 decades, top 10 lessons, and future directions.

5/17/21 – Dr. Michelle O’Donoghue is featured in Brigham Clinical & Research News!

3/1/21 – TIMI Publications for 2020 2020 Publication Graph.jpg

1/6/21 – Listen to Drs. Michelle O’Donoghue and Marc Sabatine discuss their editorial “Aspirin or P2Y12 inhibition: establishing the cornerstone of antiplatelet therapy after stenting” on the ESC Cardio Talk Podcast.

11/18/20 – TIMI Fellowship alumnus Thomas Zelniker has received the Paul Dudley White Award at the American Heart Association for the best submitted abstract from Austria, on biomarkers and MACE in DECLARE-58.  Congratulations, Thomas!

11/9/20 – Congratulations to Dr. Christian Ruff on his appointment to Associate Professor of Medicine at Harvard Medical School!_MG_0978

10/28/20 – Dr. Michelle O’Donoghue shares her experience as a woman in cardiology in the Medscape podcast, “When It’s Assumed That You’re The Cleaner, Not A Cardiologist: Gender Inequities Prevail“.

8/14/20 – Dapagliflozin not linked to adverse limb events in DECLARE-TIMI 58 is covered in Medicine Matters Diabetes.

8/12/20 – TIMI is very proud to welcome Nicholas Marston and David Berg on as TIMI Investigators.

8/6/20 – Dr. Nick Marston’s paper on the use of high-sensitivity troponin testing to improve ASCVD risk classification has been covered as the lead story in Med Page Today.

7/21/20 – Dr. Kazuma Oyama has been selected for a Young Investigator Award in Thrombosis at the European Society of Cardiology 2020 Congress for his presentation entitled, “Serial measurement of biomarkers and the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in ENGAGE AF-TIMI 48.”  Congratulations, Kaz!

7/13/20 – New publication: Effect of Dapagliflozin in Patients With HFrEF Treated With Sacubitril/Valsartan: The DAPA-HF Trial. Solomon SD, Jhund PS, Claggett BL, Dewan P, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Inzucchi SE, Desai AS, Bengtsson O, Lindholm D, Sjostrand M, Langkilde AM, McMurray JJV. JACC Heart Fail. 2020 Jul 5. pii: S2213-1779(20)30254-7.

7/13/20 – New publication: Sacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial. Mann DL, Greene SJ, Givertz MM, Vader JM, Starling RC, Ambrosy AP, Shah P, McNulty SE, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, Mohammed SF, Gilotra NA, DeVore AD, Gorodeski EZ, Desvigne-Nickens P, Hernandez AF, Braunwald E; LIFE Investigators. JACC Heart Fail. 2020 Jun 10. pii: S2213-1779(20)30272-9. doi: 10.1016/j.jchf.2020.05.005.

7/6/20 – New publication: Management of LDL-cholesterol after an acute coronary syndrome: Key comparisons of the American and European clinical guidelines to the attention of the healthcare providers. Gencer B, Giugliano RP. Clin Cardiol. 2020 Jun 29. doi: 10.1002/clc.23410.

7/2/20 – Dr. Michelle O’Donoghue’s meta-analysis highlighting the efficacy and safety of ASA discontinuation post PCI is now highlighted in NEJM Journal Watch.

6/29/20 – Dr. David Morrow has been appointed a deputy editor of European Society of Cardiology Journals.

6/29/20 – New publication: Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial. Deharo P, Ducrocq G, Bode C, Cohen M, Cuisset T, Mehta SR, Pollack CV, Wiviott SD, Rao SV, Jukema JW, Erglis A, Moccetti T, Elbez Y, Steg PG. Int J Cardiol. 2020 Jun 23. pii: S0167-5273(20)33398-2.

6/22/20 – New publication: The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y 12 Inhibitor in Patients after Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. O’Donoghue ML, Murphy SA, Sabatine MS. Circulation. 2020 Jun 19. doi: 10.1161/CIRCULATIONAHA.120.046251.

6/22/20 – New publication: The American Heart Association COVID-19 CVD Registry powered by Get With The Guidelines®. Alger HM, Rutan C, Williams Iv JH, Walchok JG, Bolles M, Hall JL, Bradley SM, Elkind MSV, Rodriguez F, Wang TY, Morrow DA, Das SR, de Lemos JA. Circ Cardiovasc Qual Outcomes. 2020 Jun 17. doi: 10.1161/CIRCOUTCOMES.120.006967.

6/22/20 – New publication: Efficacy and safety of sodium-glucose co-transporter 2 inhibition according to left ventricular ejection fraction in DAPA-HF. Dewan P, Solomon SD, Jhund PS, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sjöstrand M, Langkilde AM, Anand IS, Bělohlávek J, Chopra VK, Dukát A, Kitakaze M, Merkely B, O’Meara E, Schou M, Vinh PN, McMurray JJV; DAPA-HF Investigators and Committees. Eur J Heart Fail. 2020 Jun 15. doi: 10.1002/ejhf.1867.

6/15/20 – New publication: Pharmacogenetic-guided and clinical warfarin dosing algorithm assessments with bleeding outcomes risk-stratified by genetic and covariate subgroupsDietz N, Ruff C, Giugliano RP, Mercuri MF, Antman EM. Int J Cardiol. 2020 Mar 21. pii: S0167-5273(19)33781-7. doi: 10.1016/j.ijcard.2020.03.055.

6/8/20 – New publication: Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Anker SD, Butler J, Khan MS, Abraham WT, Bauersachs J, Bocchi E, Bozkurt B, Braunwald E, Chopra VK, Cleland JG, Ezekowitz J, Filippatos G, Friede T, Hernandez AF, Lam CSP, Lindenfeld J, McMurray JJV, Mehra M, Metra M, Packer M, Pieske B, Pocock SJ, Ponikowski P, Rosano GMC, Teerlink JR, Tsutsui H, Van Veldhuisen DJ, Verma S, Voors AA, Wittes J, Zannad F, Zhang J, Seferovic P, Coats AJS. Eur Heart J. 2020 Jun 4. pii: ehaa461. doi: 10.1093/eurheartj/ehaa461.

6/8/20 – New publication: A current review of COVID-19 for the cardiovascular specialist. Lang JP, Wang X, Moura FA, Siddiqi HK, Morrow DA, Bohula EA. Am Heart J. 2020 May 3;226:29-44. doi: 10.1016/j.ahj.2020.04.025.

6/8/20 – New publication: Left ventricle unloading strategies in ECMO: A single-center experience. Piechura LM, Coppolino A, Mody GN, Rinewalt DE, Keshk M, Ogawa M, Seethala R, Bohula EA, Morrow DA, Singh SK, Mallidi HR, Keller SP. J Card Surg. 2020 Jun 2. doi: 10.1111/jocs.14644.

6/8/20 – New publication: Coexistence and outcome of coronary artery disease in Takotsubo syndrome. Napp LC, Cammann VL, Jaguszewski M, Szawan KA, Wischnewsky M, Gili S, Knorr M, Heiner S, Citro R, Bossone E, D’Ascenzo F, Neuhaus M, Franke J, Sorici-Barb I, Noutsias M, Burgdorf C, Koenig W, Kherad B, Sarcon A, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Pott A, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Hauck C, Paolini C, Bilato C, Imori Y, Kato K, Kobayashi Y, Opolski G, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Dichtl W, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, El-Battrawy I, Akin I, Gilyarova E, Shilova A, Gilyarov M, Horowitz JD, Polednikova K, Tousek P, Widimský P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Di Mario C, Prasad A, Rihal CS, Schulze PC, Bianco M, Crea F, Borggrefe M, Maier LS, Pinto FJ, Braun-Dullaeus RC, Rottbauer W, Katus HA, Hasenfuß G, Tschöpe C, Pieske BM, Thiele H, Schunkert H, Böhm M, Felix SB, Münzel T, Bax JJ, Bauersachs J, Braunwald E, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C. Eur Heart J. 2020 Jun 2. pii: ehaa210. doi: 10.1093/eurheartj/ehaa210.

6/8/20 – New publication: MRI-EEG correlation for outcome prediction in postanoxic myoclonus: A multicenter study. Beuchat I, Sivaraju A, Amorim E, Gilmore EJ, Dunet V, Rossetti AO, Westover MB, Hsu L, Scirica BM, Silva D, Tang K, Lee JW. Neurology. 2020 Jun 1. pii: 10.1212/WNL.0000000000009610. doi: 10.1212/WNL.0000000000009610.

6/8/20 – New publication: Reversal Agents: What We Have and What We Can Expect. Ruff CT. J Innov Card Rhythm Manag. 2018 Apr 15;9(4):3108-3114. doi: 10.19102/icrm.2018.090403. eCollection 2018 Apr. Review.

5/25/20 – New publication: Efficacy of Evolocumab on Cardiovascular Outcomes in Patients With Recent Myocardial Infarction: A Prespecified Secondary Analysis From the FOURIER Trial. Gencer B, Mach F, Murphy SA, De Ferrari GM, Huber K, Lewis BS, Ferreira J, Kurtz CE, Wang H, Honarpour N, Keech AC, Sever PS, Pedersen TR, Sabatine MS, Giugliano RP. JAMA Cardiol. 2020 May 20. doi: 10.1001/jamacardio.2020.0882.

5/26/20 – New publication: Non-Vitamin K Antagonist Oral Anticoagulant for Atrial Fibrillation in Obese Patients. Wang SY, Giugliano RP. Am J Cardiol. 2020 Apr 23. pii: S0002-9149(20)30384-2. doi: 10.1016/j.amjcard.2020.04.016. [Epub ahead of print] Review.

5/11/20 – New publication: HRS white paper on atrial fibrillation centers of excellence: Rationale, considerations, and goals. Piccini JP Sr, Allred J, Bunch TJ, Deering TF, Di Biase L, Hussein AA, Lewis WR, Mittal S, Natale A, Osorio J, Packer DL, Ruff C, Russo AM, Sanders P, Seiler A, Slotwiner D, Hills MT, Turakhia MP, Van Gelder IC, Varosy PD, Verma A, Volgman AS, Wood KA, Deneke T. Heart Rhythm. 2020 May 3. pii: S1547-5271(20)30407-0. doi: 10.1016/j.hrthm.2020.04.033.

5/11/20 – New publication: Cognition After Lowering LDL-Cholesterol With Evolocumab. Gencer B, Mach F, Guo J, Im K, Ruzza A, Wang H, Kurtz CE, Pedersen TR, Keech AC, Ott BR, Sabatine MS, Giugliano RP; FOURIER Investigators. J Am Coll Cardiol. 2020 May 12;75(18):2283-2293. doi: 10.1016/j.jacc.2020.03.039.

5/11/20 – New publication: Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. J Am Heart Assoc. 2020 May 5:e015331. doi: 10.1161/JAHA.119.015331.

5/11/20 – New publication: Extended Venous Thromboembolism Prophylaxis in Medically Ill Patients: An NATF Anticoagulation Action Initiative. Barkoudah E, Piazza G, Hecht TEH, Grant P, Deitelzweig S, Fang MC, Fanikos J, Kao CK, Barnes GD, Chen T, Ramishvili T, Schnipper JL, Goldstein JN, Ruff CT, Kaatz S, Schwartz A, Connors JM, Goldhaber SZ. Am J Med. 2020 May;133 Suppl 1:1-27. doi: 10.1016/j.amjmed.2019.12.001.

5/4/20 – New publication: Prespecified Analysis of the FOURIER Randomized Clinical Trial. Wiviott SD, Giugliano RP, Morrow DA, De Ferrari GM, Lewis BS, Huber K, Kuder JF, Murphy SA, Forni DM, Kurtz CE, Honarpour N, Keech AC, Sever PS, Pedersen TR, Sabatine MS. JAMA Cardiol. 2020 Apr 29. doi: 10.1001/jamacardio.2020.0764.

5/4/20 – New publication: An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial. Bergmark BA, O’Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Ceška R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, Mach F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS. JAMA Cardiol. 2020 Apr 29. doi: 10.1001/jamacardio.2020.0728.

4/27/20 – New publication: No Significant Relationship Between Ticagrelor and Sleep Apnea in Large, Randomized, Blinded Trials.  Sabatine MS, Hiatt WR, Goto S, Johnston SC, Bonaca MP, Steg PG, Bhatt DL, Cannon CP, Andersson M, Wallentin L.  JACC Cardiovasc Interv. 2020 Apr 27;13(8):1012-1014. doi: 10.1016/j.jcin.2020.02.009.

4/27/20 – New publication: Incidence, predictors and prognosis of respiratory support in non-ST segment elevation myocardial infarction.  Metkus T, Miller PE, Alviar CL, Jentzer JC, van Diepen S, Katz JN, Morrow DA, Schulman S, Eid S.  Eur Heart J Acute Cardiovasc Care. 2020 Apr 23:2048872620919947. doi: 10.1177/2048872620919947.

4/27/20 – New publication: Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis.  Giugliano RP, Pedersen TR, Saver JL, Sever PS, Keech AC, Bohula EA, Murphy SA, Wasserman SM, Honarpour N, Wang H, Lira Pineda A, Sabatine MS; FOURIER Investigators.  Stroke. 2020 Apr 21:STROKEAHA119027759. doi: 10.1161/STROKEAHA.119.027759.

4/20/20 – New publication: Admission diagnosis and mortality risk prediction in a contemporary cardiac intensive care unit population. Jentzer JC, van Diepen S, Murphree DH, Ismail AS, Keegan MT, Morrow DA, Barsness GW, Anavekar NS. Am Heart J. 2020 Feb 28;224:57-64. doi: 10.1016/j.ahj.2020.02.018.

4/20/20 – New publication: Disruptive Modifications to Cardiac Critical Care Delivery During the Covid-19 Pandemic: An International Perspective. Katz JN, Sinha SS, Alviar CL, Dudzinski DM, Gage A, Brusca SB, Flanagan MC, Welch T, Geller BJ, Miller PE, Leonardi S, Bohula EA, Price S, Chaudhry SP, Metkus TS, O’Brien CG, Sionis A, Barnett CF, Jentzer JC, Solomon MA, Morrow DA, van Diepen S. J Am Coll Cardiol. 2020 Apr 14. pii: S0735-1097(20)35002-6. doi: 10.1016/j.jacc.2020.04.029.

4/20/20 – New publication: Use of Temporary Mechanical Circulatory Support for Management of Cardiogenic Shock Before and After the United Network for Organ Sharing Donor Heart Allocation System Changes. Varshney AS, Berg DD, Katz JN, Baird-Zars VM, Bohula EA, Carnicelli AP, Chaudhry SP, Guo J, Lawler PR, Nativi-Nicolau J, Sinha SS, Teuteberg JJ, van Diepen S, Morrow DA; Critical Care Cardiology Trials Network Investigators. JAMA Cardiol. 2020 Apr 15. doi: 10.1001/jamacardio.2020.0692.

4/20/20 – New publication: COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies. Atri D, Siddiqi HK, Lang J, Nauffal V, Morrow DA, Bohula EA. JACC Basic Transl Sci. 2020 Apr 10. doi: 10.1016/j.jacbts.2020.04.002.

4/13/20 – New publication: Understanding the Sex Paradox After Percutaneous Coronary Intervention: Leveling the Playing Field. O’Donoghue ML, Sarma AA. J Am Coll Cardiol. 2020 Apr 14;75(14):1641-1643. doi: 10.1016/j.jacc.2020.02.048.

4/6/20 – New publication: The Promise of Mobile Health in Managing Atrial Fibrillation. Ruff CT. J Am Coll Cardiol. 2020 Apr 7;75(13):1535-1537. doi: 10.1016/j.jacc.2020.02.039.

4/6/20 – New publication: Safety of dapagliflozin in a broad population of patients with type 2 diabetes – analyses from the DECLARE – TIMI 58 study. Cahn A, Raz I, Bonaca M, Mosenzon O, Murphy SA, Yanuv I, Rozenberg A, Wilding JPH, Bhatt DL, McGuire DK, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Jermendy G, Hadjadj S, Langkilde AM, Sabatine MS, Wiviott SD, Leiter LA. Diabetes Obes Metab. 2020 Apr 2. doi: 10.1111/dom.14041.

4/6/20 – New publication: Managing Stable Ischemic Heart Disease. Antman EM, Braunwald E. N Engl J Med. 2020 Mar 30. doi: 10.1056/NEJMe2000239. PMID: 32227752

4/6/20 – New publication: The Effect of PCSK9 Inhibition on the Risk of Venous Thromboembolism. Marston NA, Gurmu Y, Melloni GEM, Bonaca M, Gencer B, Sever PS, Pedersen TR, Keech AC, Roselli C, Lubitz SA, Ellinor PT, O’Donoghue ML, Giugliano RP, Ruff CT, Sabatine MS. Circulation. 2020 Mar 29. doi: 10.1161/CIRCULATIONAHA.120.046397.

4/6/20 – New publication: Contemporary Trends in Prescription of Dipeptidyl Peptidase-4 Inhibitors in the Context of US Food and Drug Administration Warnings of Heart Failure Risk. Vaduganathan M, Singh A, Sharma A, Januzzi JL Jr, Scirica BM, Butler J, Zannad F, McGuire DK, Cannon CP, Bhatt DL. Am J Cardiol. 2020 Mar 4. pii: S0002-9149(20)30175-2. doi: 10.1016/j.amjcard.2020.01.053.

3/30/20 – New publication: Effects of dapagliflozin in DAPA-HF according to background heart failure therapy. Docherty KF, Jhund PS, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sjöstrand M, Langkilde AM, Desai AS, Diez M, Howlett JG, Katova T, Ljungman CEA, O’Meara E, Petrie MC, Schou M, Verma S, Vinh PN, Solomon SD, McMurray JJV. Eur Heart J. 2020 Mar 28. pii: ehaa183. doi: 10.1093/eurheartj/ehaa183.

3/30/20 – New publication: Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes. Petrie MC, Verma S, Docherty KF, Inzucchi SE, Anand I, Belohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett J, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O’Meara E, Vinh PN, Schou M, Tereshchenko S, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD, Johanson P, Greasley PJ, Boulton D, Bengtsson O, Jhund PS, McMurray JJV. JAMA. 2020 Mar 27. doi: 10.1001/jama.2020.1906.

3/16/20 – New publication: Nonculprit Lesion Myocardial Infarction Following Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome. Scirica BM, Bergmark BA, Morrow DA, Antman EM, Bonaca MP, Murphy SA, Sabatine MS, Braunwald E, Wiviott SD. J Am Coll Cardiol. 2020 Mar 17;75(10):1095-1106. doi: 10.1016/j.jacc.2019.12.067.

3/9/20 – New publication: Cardiology and Therapy: A Summary of 2019 and Key Areas of Emerging Research in 2020. Menown IBA, Giugliano R, Zeymer U. Cardiol Ther. 2020 Mar 6. doi: 10.1007/s40119-020-00166-7.

3/2/20 – New publication: Cardiovascular and renal benefits of dapagliflozin in patients with short and long-standing type 2 diabetes: analyses from the DECLARE-TIMI 58 trial. Bajaj HS, Raz I, Mosenzon O, Murphy SA, Rozenberg A, Yanuv I, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Sabatine MS, Wiviott SD, Cahn A. Diabetes Obes Metab. 2020 Feb 23. doi: 10.1111/dom.14011.

3/2/20 – New publication: Percutaneous right ventricular assist device-supported ventricular tachycardia ablation in a patient with severe right ventricular dysfunction. Aguilar M, Tsao AL, Croce KJ, Sauer W, Morrow DA, Tedrow UB. HeartRhythm Case Rep. 2019 Nov 4;6(2):72-76. doi: 10.1016/j.hrcr.2019.10.019. eCollection 2020 Feb.

2/24/20 – New publication: Association of Hypertrophic Obstructive Cardiomyopathy With Outcomes Following Transcatheter Aortic Valve Replacement. Bandyopadhyay D, Chakraborty S, Amgai B, Kapadia SR, Braunwald E, Naidu SS, Kalra A.JAMA Netw Open. 2020 Feb 5;3(2):e1921669. doi: 10.1001/jamanetworkopen.2019.21669.

2/24/20 – New publication: 2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists: A Report of the ACC Competency Management Committee. Writing Committee Members, Yancy CW, Drazner MH, Coffin ST, Cornwell W 3rd, Desai S, Erwin JP 3rd, Ginwalla M, Harshaw-Ellis KS, Horwich T, Kittleson M, Lala A, Lewsey SC, Marine JE, Martin CM, Meehan K, Morrow DA, Schlendorf K, Smith JW, Stevens GR. J Am Coll Cardiol. 2020 Feb 14. pii: S0735-1097(19)37741-1. doi: 10.1016/j.jacc.2019.09.030.

2/24/20 – New publication: Meta-Analysis of Intraocular Bleeding With Dual Antiplatelet Therapy Using P2Y12 Inhibitors Prasugrel or Ticagrelor. Sun MT, Huang S, Wiviott SD, Antman EM, Roe MT, Ohman EM, Neely M, Wallentin L, Wong CX. Am J Cardiol. 2020 Jan 29. pii: S0002-9149(20)30053-9. doi: 10.1016/j.amjcard.2020.01.012.

2/24/20 – New publication: Muscle Complaints or Events in Patients Randomized to Simvastatin or Ezetimibe/Simvastatin. Nanna MG, Navar AM, Giugliano RP, White JA, Lokhnygina Y, Mitchel YB, Musliner TA, Cannon CP, Blazing MA. J Am Coll Cardiol. 2020 Feb 25;75(7):835-837. doi: 10.1016/j.jacc.2019.12.022.

2/17/20 – New publication: Ejection fraction versus B-type natriuretic peptide for revascularization strategy in left main disease: two sides of the same coin or a wooden nickel? Furtado RHM, Bergmark B. Eur J Heart Fail. 2020 Feb 11. doi: 10.1002/ejhf.1717.

2/17/20 – New publication: Positive Pressure Ventilation in Cardiogenic Shock: Review of the Evidence and Practical Advice for Patients With Mechanical Circulatory Support. Alviar CL, Rico-Mesa JS, Morrow DA, Thiele H, Miller PE, Maselli DJ, van Diepen S. Can J Cardiol. 2020 Feb;36(2):300-312. doi: 10.1016/j.cjca.2019.11.038. Epub 2019 Dec 12. Review.

2/10/20 – New publication: Efficacy and safety of edoxaban in patients with diabetes mellitus in the ENGAGE AF-TIMI 48 trial. Plitt A, Ruff CT, Goudev A, Morais J, Ostojic MC, Grosso MA, Lanz HJ, Park JG, Antman EM, Braunwald E, Giugliano RP. Int J Cardiol. 2020 Jan 30. pii: S0167-5273(19)35229-5. doi: 10.1016/j.ijcard.2020.01.009.

2/10/20 – New publication: LDL-cholesterol lowering with evolocumab, and outcomes according to age and sex in patients in the FOURIER Trial. Sever P, Gouni-Berthold I, Keech A, Giugliano R, Pedersen TR, Im K, Wang H, Knusel B, Sabatine MS, O’Donoghue ML. Eur J Prev Cardiol. 2020 Feb 4:2047487320902750. doi: 10.1177/2047487320902750.

2/10/20 – New publication: What Lessons Have We Learned and What Remains to be Clarified for PCSK9 Inhibitors? A Review of FOURIER and ODYSSEY Outcomes Trials. Furtado RHM, Giugliano RP. Cardiol Ther. 2020 Feb 5. doi: 10.1007/s40119-020-00163-w. Review.

2/3/20TIMI Study Group and Brigham and Women’s researchers receive American Heart Association grant to develop strategies to reduce adverse cardiovascular events in Type 2 Diabetes Mellitus.

2/3/20 – New publication: Clinical Benefit of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review. Zelniker TA, Braunwald E. J Am Coll Cardiol. 2020 Feb 4;75(4):435-447. doi: 10.1016/j.jacc.2019.11.036. Review.

2/3/20 – New publication: Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review. Zelniker TA, Braunwald E. J Am Coll Cardiol. 2020 Feb 4;75(4):422-434. doi: 10.1016/j.jacc.2019.11.031. Review.

2/3/20 – New publication: Effect of vorapaxar on cardiovascular and limb outcomes in patients with peripheral artery disease with and without coronary artery disease: Analysis from the TRA 2°P-TIMI 50 trial. Qamar A, Morrow DA, Creager MA, Scirica BM, Olin JW, Beckman JA, Murphy SA, Bonaca MP. Vasc Med. 2020 Jan 30:1358863X19892690. doi: 10.1177/1358863X19892690.

2/3/20 – New publication: Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions. Sharma A, Pagidipati NJ, Califf RM, McGuire DK, Green JB, Demets D, George JT, Gerstein HC, Hobbs T, Holman RR, Lawson FC, Leiter LA, Pfeffer MA, Reusch J, Riesmeyer JS, Roe MT, Rosenberg Y, Temple R, Wiviott SD, McMurray JJV, Granger CB. Circulation. 2020 Jan 29. doi: 10.1161/CIRCULATIONAHA.119.041022.

2/3/20 – New publication: Response by Bergmark et al to Letter Regarding Article, “Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial”.  Bergmark BA, Bhatt DL, McGuire DK, Scirica BM. Circulation. 2020 Jan 28;141(4):e57-e58. doi: 10.1161/CIRCULATIONAHA.119.044819. Epub 2020 Jan 27.

2/3/20 – New publication: Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial. Zelniker TA, Bonaca MP, Furtado R, Mosenzon O, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Budaj A, Kiss RG, Padilla F, Gause-Nilsson I, Langkilde AM, Raz I, Sabatine MS, Wiviott SD. Circulation. 2020 Jan 27. doi: 10.1161/CIRCULATIONAHA.119.044183.

2/3/20 – New publication: Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. van Diepen S, Tymchak W, Bohula EA, Park JG, Daniels LB, Phreaner N, Barnett CF, Kenigsberg BB, DeFilippis A, Singam NS, Barsness GW, Jentzer JC, Ternus B, Morrow DA, Katz JN; Critical Care Cardiology Trials Network Investigators. Am Heart J. 2020 Jan 15;222:8-14. doi: 10.1016/j.ahj.2020.01.005.

1/20/2020 – In a post-hoc analysis from DECLARE-TIMI 58, dapagliflozin reduced the first, as well as the total number, of AF/AFL events.

1/20/2020 – New publication: The Fourth Universal Definition of Myocardial Infarction and the Emerging Importance of Myocardial Injury. Morrow DA. Circulation. 2020 Jan 21;141(3):172-175. doi: 10.1161/CIRCULATIONAHA.119.044125. Epub 2020 Jan 20.

1/20/2020 – New publication: American Heart Association Vascular Disease Strategically Focused Research Network. Barnett JV1, Beckman JA, Bonaca MP, Carnethon MR, Cassis LA, Creager MA, Daugherty A, Feinberg MW, Freiberg MS, Goodney PP, Greenland P, Leeuwenburgh C, LeMaire SA, McDermott MM, Sabatine MS, Shen YH, Wasserman DH, Webb NR, Wells QS. Arterioscler Thromb Vasc Biol. 2020 Jan 23:ATVBAHA120313967. doi: 10.1161/ATVBAHA.120.313967.

1/20/2020 – New publication: Morphine and Cardiovascular Outcomes Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography. Furtado RHM, Nicolau JC, Guo J, Im K, White JA, Sabatine MS, Newby LK, Giugliano RP. J Am Coll Cardiol. 2020 Jan 28;75(3):289-300. doi: 10.1016/j.jacc.2019.11.035.

1/20/2020Plavix Efficacy Blunted With Opioid In The Picture

1/20/2020 – Clopidigrel Interaction With Morphine In ACS Linked To More Ischemic Events

1/20/2020 – New publication: Atrial Failure as a Clinical Entity: JACC Review Topic of the Week. Bisbal F, Baranchuk A, Braunwald E, Bayés de Luna A, Bayés-Genís A. J Am Coll Cardiol. 2020 Jan 21;75(2):222-232. doi: 10.1016/j.jacc.2019.11.013. Review.

1/13/2020 – New publication: Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Shah S et al. Nat Commun. 2020 Jan 9;11(1):163. doi: 10.1038/s41467-019-13690-5.

1/9/2020TIMI study VESALIUS-CV, studying the clinical efficacy of evolocumab to prevent a first MI or stroke, one of top five Brigham Research Awards for 2019.

1/6/2020 – Notable TIMI publications from 2019Graph

1/6/2020 – New publication: Relation of White Blood Cell Count to Bleeding and Ischemic Events in Patients With Acute Coronary Syndrome (from the ATLAS ACS 2-TIMI 51 Trial). Alkhalfan F, Nafee T, Yee MK, Chi G, Kalayci A, Plotnikov A, Braunwald E, Gibson CM. Am J Cardiol. 2019 Dec 9. pii: S0002-9149(19)31363-3. doi: 10.1016/j.amjcard.2019.12.007.

12/30/2019 – New publication: Outcomes of Women Compared With Men After Non-ST-Segment Elevation Acute Coronary Syndromes. Sarma AA, Braunwald E, Cannon CP, Guo J, Im K, Antman EM, Gibson CM, Newby LK, Giugliano RP, Morrow DA, Wiviott SD, Sabatine MS, O’Donoghue ML. J Am Coll Cardiol. 2019 Dec 17;74(24):3013-3022. doi: 10.1016/j.jacc.2019.09.065. Epub 2019 Dec 9.

12/23/2019: “Metformin use and CV outcomes: Observations from the SAVOR-TIMI 53 trial”, published in Circulation, has been selected for top 10 Journal Scans of 2019!

12/23/2019 – New publication: Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. Cahn A, Mosenzon O, Wiviott SD, Rozenberg A, Yanuv I, Goodrich EL, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS, Raz I. Diabetes Care. 2019 Dec 16. pii: dc191476. doi: 10.2337/dc19-1476.

12/23/2019 – New publication: Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues. Butler J, Packer M, Greene SJ, Fiuzat M, Anker SD, Anstrom KJ, Carson PE, Cooper LB, Fonarow GC, Hernandez AF, Januzzi JL Jr, Jessup M, Kalyani RR, Kaul S, Kosiborod M, Lindenfeld J, McGuire DK, Sabatine MS, Solomon SD, Teerlink JR, Vaduganathan M, Yancy CW, Stockbridge N, O’Connor CM. Circulation. 2019 Dec 17;140(25):2108-2118. doi: 10.1161/CIRCULATIONAHA.119.042155. Epub 2019 Dec 16.

12/16/2019 – New publication: Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure: Secondary Analysis of the Open-label Extension of the PIONEER-HF Trial. DeVore AD, Braunwald E, Morrow DA, Duffy CI, Ambrosy AP, Chakraborty H, McCague K, Rocha R, Velazquez EJ; PIONEER-HF Investigators.  JAMA Cardiol. 2019 Dec 11. doi: 10.1001/jamacardio.2019.4665.

12/16/2019 – New publication:  Respiratory support in acute heart failure with preserved vs reduced ejection fraction. Metkus TS, Stephens RS, Schulman S, Hsu S, Morrow DA, Eid SM.  Clin Cardiol. 2019 Dec 11. doi: 10.1002/clc.23317.

12/16/2019 – New publication:  Current Smoking Is Associated With Lower Concentrations of High-Sensitivity Cardiac Troponin T in Patients With Stable Coronary Artery Disease: The PEACE Trial. Skranes JB, Claggett BL, Myhre PL, Lyngbakken MN, Solomon SD, Sabatine MS, Pfeffer MA, Omland T.  Circulation. 2019 Dec 10;140(24):2044-2046. doi: 10.1161/CIRCULATIONAHA.119.041991. Epub 2019 Dec 9.

12/16/2019 – New publication:  Veno-Arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock: An Introduction for the Busy Clinician. Eckman PM, Katz JN, El Banayosy A, Bohula EA, Sun B, van Diepen S.  Circulation. 2019 Dec 10;140(24):2019-2037. doi: 10.1161/CIRCULATIONAHA.119.034512. Epub 2019 Dec 9.

12/16/2019 – New publication:  Baseline Characteristics of the VANISH Cohort. Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY.  Circ Heart Fail. 2019 Dec;12(12):e006231. doi: 10.1161/CIRCHEARTFAILURE.119.006231. Epub 2019 Dec 9.

12/10/2019: Congratulations to Drs. Sabatine, Braunwald, Antman, Giugliano, Wiviott and Sabina Murphy for being recognized on the Web of Science List of 2019 Highly Cited Researchers!

12/09/2019 – New publication:  Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54.  Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP.  Eur Heart J. 2019 Dec 7. pii: ehz821. doi: 10.1093/eurheartj/ehz821. [Epub ahead of print].

12/09/2019: Dr. Marc Sabatine gives Cardiology Grand Rounds at Yale School of Medicine on “Treating Dyslipidemia in 2020: Molds, Monoclonals & mRNA Silencing”. Tomorrow, December 10 at 8am, Fitkin Amphitheater-LMP 1094, 330 Cedar Street.

12/05/2019: Dr. David Morrow gives NYU Cardiology Grand Rounds tomorrow on “Preparing Critical Care Cardiology for the Next Era: Can we move from ‘best’ practice to evidence-based care?” Friday, December 6 @ 8am, NYU Langone Health Skirball 4th Floor Seminar Room.

12/2/2019 – New Publication:  Left atrial structure and function and the risk of death or heart failure in atrial fibrillation. Inciardi RM, Giugliano RP, Claggett B, Gupta DK, Chandra A, Ruff CT, Antman EM, Mercuri MF, Grosso MA, Braunwald E, Solomon SD; ENGAGE AF-TIMI 48 Investigators. Eur J Heart Fail. 2019 Nov 27. doi: 10.1002/ejhf.1606. [Epub ahead of print].

11/18/2019 – View the list of TIMI presentations at the 2019 AHA Annual Scientific Sessions.

11/18/2019– Visit the TIMI Booth at the AHA Scientific Sessions in Philadelphia!Booth Set Up 2019 AHA

11/17/2019 – New Publication: Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial. Kosiborod MN, Jhund P, Docherty KF, Diez M, Petrie MC, Verma S, Nicolau JC, Merkely B, Kitakaze M, DeMets DL, Inzucchi SE, Køeber L, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Bengtsson O, Lindholm D, Niklasson A, Sjöstrand M, Langkilde AM, McMurray JJV. Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044138.

11/17/2019 – New Publication: Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age: Insights From DAPA-HF.Martinez FA, Serenelli M, Nicolau JC, Petrie MC, Chiang CE, Tereshchenko S, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Ponikowski P, Sabatine MS, Demets DL, Dutkiewicz-Piasecka M, Bengtsson O, Sjöstrand M, Langkilde AM, Jhund PS, McMurray JJV. Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044133.

11/14/2019 – New Publication: Rationale and design of a navigator-driven remote optimization of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction. Blood AJ, Fischer CM, Fera LE, MacLean TE, Smith KV, Dunning JR, Bosque-Hamilton JW, Aronson SJ, Gaziano TA, MacRae CA, Matta LS, Mercurio-Pinto AA, Murphy SN, Scirica BM, Wagholikar K, Desai AS. Clin Cardiol. 2019 Nov 14. doi: 10.1002/clc.23291.

11/12/2019 – New Publication: Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Circ Heart Fail. 2019 Nov;12(11):e006635. doi: 10.1161/CIRCHEARTFAILURE.119.006635. Epub 2019 Nov 11.

11/12/2019 – New Publication: Reply: Anticoagulants in Atrial Fibrillation and Liver Disease. Qamar A, Antman EM, Giugliano RP. J Am Coll Cardiol. 2019 Nov 12;74(19):2436-2437. doi: 10.1016/j.jacc.2019.09.010.

11/11/2019 – New Publication: Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial. Marston NA, Kamanu FK, Nordio F, Gurmu Y, Roselli C, Sever PS, Pedersen TR, Keech AC, Wang H, Lira Pineda A, Giugliano RP, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. Circulation. 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.043805.

11/11/2019 – New Publication: REDUCE-IT USA: Results from the 3,146 Patients Randomized in the United States. Bhatt DL, Miller M, Brinton EA, Jacobson TA, Steg PG, Ketchum SB, Doyle RT, Juliano RA, Jiao L, Granowitz C, Tardif JC, Olshansky B, Chung MK, Gibson CM, Giugliano RP, Budoff MJ, Ballantyne CM; REDUCE-IT Investigators. Circulation. 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.044440.

11/7/2019 – New Publication: Clinical and regulatory landscape for cardiogenic shock: A report from the Cardiac Safety Research Consortium ThinkTank on cardiogenic shock. Samsky M, Krucoff M, Althouse AD, Abraham WT, Adamson P, Aguel F, Bilazarian S, Dangas GD, Gilchrist IC, Henry TD, Hochman JS, Kapur NK, Laschinger J, Masters RG, Michelson E, Morrow DA, Morrow V, Ohman EM, Pina I, Proudfoot AG, Rogers J, Sapirstein J, Senatore F, Stockbridge N, Thiele H, Truesdell AG, Waksman R, Rao S. Am Heart J. 2019 Nov 7;219:1-8. doi: 10.1016/j.ahj.2019.10.006.

11/5/2019 – New Publication: The DAPA-HF Trial: A Momentous Victory in the War against Heart Failure. Bhatt DL, Verma S, Braunwald E. Cell Metab. 2019 Nov 5;30(5):847-849. doi: 10.1016/j.cmet.2019.10.008.

11/5/2019 – New Publication: Efficacy and Safety of Edoxaban Compared to Warfarin According to the Burden of Diseases in Patients with Atrial Fibrillation: Insights from the ENGAGE AF-TIMI 48. Nicolau AM, Corbalan R, Nicolau JC, Ruff CT, Zierhut W, Kerschnitzki M, Duris T, Juul-Möller S, Voitk J, Trevisan M, Nordio F, Antman EM, Giugliano RP. Eur Heart J Cardiovasc Pharmacother. 2019 Nov 5. pii: pvz061. doi: 10.1093/ehjcvp/pvz061.

11/1/2019 – New Publication: Diastolic Dysfunction in Patients with Human Immunodeficiency Virus Receiving Antiretroviral Therapy: Results from the CHART Study. Butler J, Greene SJ, Shah SH, Shah SJ, Anstrom KJ, Kim RJ, Kalogeropoulos AP, Velazquez EJ, Hernandez AF, Desvigne-Nickens P, Scherzer R, Hsue PY, Braunwald E.
J Card Fail . 2019 Nov 1. pii: S1071-9164(19)30584-6. doi: 10.1016/j.cardfail.2019.10.011.

10/29/2019 – New Publication: Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study. McClung MR, O’Donoghue ML, Papapoulos SE, Bone H, Langdahl B, Saag KG, Reid IR, Kiel DP, Cavallari I, Bonaca MP, Wiviott SD, de Villiers T, Ling X, Lippuner K, Nakamura T, Reginster JY, Rodriguez-Portales JA, Roux C, Zanchetta J, Zerbini CAF, Park JG, Im K, Cange A, Grip LT, Heyden N, DaSilva C, Cohn D, Massaad R, Scott BB, Verbruggen N, Gurner D, Miller DL, Blair ML, Polis AB, Stoch SA, Santora A, Lombardi A, Leung AT, Kaufman KD, Sabatine MS; LOFT Investigators. Lancet Diabetes Endocrinol. 2019 Oct 29. pii: S2213-8587(19)30346-8. doi: 10.1016/S2213-8587(19)30346-8.

10/29/2019 – New Publication: Response by Kato et al to Letter Regarding Article, “Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus”. Kato ET, Sabatine MS, Wiviott SD. Circulation. 2019 Oct 29;140(18):e740-e741. doi: 10.1161/CIRCULATIONAHA.119.042848. Epub 2019 Oct 28.

10/23/2019 – New Publication: Efficacy and safety of vorapaxar for secondary prevention in low body weight in patients with atherosclerosis: analyses from the TRA 2°P-TIMI 50 Trial. Xu H, Bonaca MP, Goodrich E, Scirica BM, Morrow DA. Eur Heart J Acute Cardiovasc Care. 2019 Oct 23:2048872619883354. doi: 10.1177/2048872619883354.

10/21/2019–  TIMI is proud to report that dapaglifozin is now approved by the FDA for the prevention of hospitalization for heart failure in patients with type 2 diabetes.

08/14/2019 – View the list of TIMI presentations and sessions at the 2019 ESC HERE.

07/17/2019 – New Publication: Bach, Cannon, Giugliano et al., Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial.

07/01/2019 – Now in Print: Murphy et al., Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease: A Prespecified Analysis From the FOURIER Trial. JAMA Cards 2019

03/15/2019 – Visit us at Booth 1028 at ACC.19 in New Orleans!  View our list of presentions here.

02/21/2019 – New Publication: Zelniker et al.,Comparison of the Effects of Glucagon-Like Peptide Receptor Agonists and Sodium-Glucose Co-Transporter 2 Inhibitors for Prevention of Major Adverse Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus.The Lancet 2019.

01/24/2019 – New Publication: Wiviott et al., Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. NEJM 2019.

01/15/2019 – New Publication: Scirica et al.,Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial. Circulation 2019.

11/05/2018 – Visit us at Booth 1621 at AHA 2018 in Chicago!  View our list of presentions here.

10/03/2018 – New Publication: Bohula et al.,Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial. Lancet 2018.

09/20/2018 – New Publication: Bohula et al., Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients. NEJM 2018.

09/01/2018 –  New Publication: Sabatine et al., Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis. JAMA Cards 2018.

01/23/2018 – New Publication: Bonaca et al., Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients With Peripheral Artery Disease: Insights From the FOURIER Trial . Circ 2018.

12/05/2017 – New Publication: Sabatine et al., Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial. Lancet Diabetes Endocrinol 2017.

12/01/2017 – New Publication: Giugliano et al., Clinical Efficacy and Safety of Evolocumab in High-Risk Patients Receiving a Statin: Secondary Analysis of Patients With Low LDL Cholesterol Levels and in Those Already Receiving a Maximal-Potency Statin in a Randomized Clinical Trial. JAMA Cards 2017 .

11/30/2017 – New Publication: Cavallari et al., Frequency, Predictors and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients with Symptomatic Atherosclerosis. Circ 2017.

08/28/2017 –  Slide deck and paper for achieved very low LDL-C in FOURIER now available

08/28/2017 – New Publication: Ference B et al., Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. 2017 Lancet.

03/17/2017 – FOURIER primary results slide deck and NEJM paper now available

03/12/2017 – TIMI Presentation Schedule See what TIMI Investigators are up to at ACC.17

03/14/2017 – New Publication: Koren MJ, Sabatine MS, Giugliano RP et al., Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study. 2017 JAMA Cardiol.

02/01/2017 – New Publication: Giugliano RP et al., Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial. 2017 Clin Cardiol.

11/12/2016 – AHA 2016 Scientific Sessions – TIMI Presentation Schedule

10/24/2016 – New Publication: Bonaca et al., Peripheral Revascularization in Patients With Peripheral Artery Disease With Vorapaxar: Insights From the TRA 2°P-TIMI 50 Trial. 2016 JACC Cardiovasc Interv.

 09/27/2016 – New Publication: Silverman et al., Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis. 2016 JAMA.

09/20/2016 – New Publication: Bonaca et al., Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54. 2016 Circ.

09/15/2016 – TIMI Risk Score for Secondary Prevention Calculator  — now available

06/03/2015 – New Publication: Cannon et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. MORE

05/30/2015 – New Publication: O’Donoghue et al. Rationale and design of the LosmApimod To Inhibit p38 MAP kinase as a TherapeUtic target and moDify outcomes after an acute coronary syndromE trial.MORE

04/28/2015 – OSLER CV Outcomes Paper in NEJM recommended on F1000PrimeMORE

04/28/2015 – VIDEO: PCSK9 Inhibitors: What to Know if They Come to MarketMORE

03/24/2015 – VIDEO: New IMPROVE-IT analyses reinforce benefits of greater cholesterol reduction MORE


03/14/2015 – New Publication: Bonaca et al. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction MORE

03/05/2015 – TIMI presentations at ACC.15 MORE

03/04/2015  – Genetic Risk Linked to Clinical Benefit of Statin Therapy MORE

03/03/2015  – New Publication: Mega et al. Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials MORE

01/26/2015 – Preliminary list of TIMI presentations at ACC.15 MORE

01/14/2015 – PEGASUS-TIMI 54 meets its primary endpoint. MORE

01/09/2015 – Edoxaban (Savaysa) studied in ENGAGE AF-TIMI 48 is approved by FDA. MORE

12/31/2014 – New Publication: Udell et al. Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial. MORE

12/23/2014 – New Publication: Bonaca et al. Prognostic performance of a high-sensitivity assay for cardiac troponin I after non-ST elevation acute coronary syndrome: Analysis from MERLIN-TIMI 36. MORE

12/09/2014 –  New Publication: Bonaca et al. New Ischemic Stroke and Outcomes With Vorapaxar Versus Placebo: Results From the TRA 2°P-TIMI 50 Trial. MORE

12/09/2014 –  New Publication: Bonaca et al. Coronary Stent Thrombosis With Vorapaxar Versus Placebo: Results From the TRA 2°P-TIMI 50 Trial.MORE

11/18/2014 –  IMPROVE IT-TIMI 40 Late Breaking Clinical Trial – Slides Available. MORE

11/14/2014 –  IMPROVE IT-TIMI 40 Late Breaking Clinical Trial at the American Heart Association Annual Meeting. MORE

11/12/2014 –  TIMI will present several abstracts at AHA 2014.PDF

11/14/2014 –  IMPROVE IT-TIMI 40 Late Breaking Clinical Trial at the American Heart Association Annual Meeting. MORE

11/12/2014 – TIMI will present several abstracts at AHA 2014. PDF

09/18/2014 – Today at 1pm, a special BWH Cardiovascular Grand Rounds – The TIMI Study Group: 30 Years of Cardiovascular Clinical Trials. Shapiro Building, 1st floor.

09/10/2014 – New Publication: O’Donoghue, et al. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. MORE

09/04/2014 – New Publication: Scirica, et al. Heart Failure, Saxagliptin and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial. MORE

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