Progressive changes in cardiac critical care have driven a need for innovation in research and clinical care. The Critical Care Cardiology Trials Network (CCCTN) is a collaborative research network drawn from national leaders in critical care cardiology and coordinated by the TIMI Study Group. Our mission is to design and execute observational studies and clinical trials that will advance the care of patients who require cardiac critical care. Learn about the CCCTN COVID-PACT clinical trial, a multicenter, randomized, open-label, 2 x 2 factorial design trial of full-dose anticoagulation vs. standard-dose prophylactic anticoagulation and antiplatelet therapy vs. no antiplatelet therapy on the risk of venous or arterial thrombotic events in ICU patients with COVID-19. Study patients will be followed until their 28th day or hospital discharge, whichever comes first.
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PRESENTATIONS
CCCTN MCS Shock (Berg, AHA 2019)
Temporary Mechanical Circulatory Support Use In Tertiary Cardiac Intensive Care Units Before And After The UNOS Heart Transplantation Allocation System Update: Insights From The Critical Care Cardiology Trials Network (CCCTN) Registry (Varshney, ACC 2020)
In-Hospital vs Out-of-Hospital Cardiac Arrest in Patients Presenting to Cardiac Intensive Care Units From the Critical Care Cardiology Trials Network (CCCTN) (Carnicelli, AHA 2020)
De Novo vs. Acute-on-Chronic Presentations of Heart Failure Associated Cardiogenic Shock in CICUs Data From the Critical Care Cardiology Trials Network (CCCTN) (Bhatt, ACC 2021)
Clinical Characteristics And Outcomes Of Older Patients In Cardiac Intensive Care Units- From The Critical Care Cardiology Trials Network Registry (Alviar, ACC 2021)
Multi-Marker Risk Assessment in Patients Hospitalized with COVID-19 (Bhatt, AHA 2021)
Elucidating Clinical Phenotypes of Patients with Mixed Shock Admitted to Cardiac Intensive Care Units. Insights from the Critical Care Cardiology Trial. (Dewanjee, AHA 2021)
Clinician and Algorithmic Application of the 2019 and 2022 SCAI Shock Stages in the CCCTN (Patel, ACC 2022)
Characteristics and Outcomes of Adults with Congenital Heart Disease in the CICU-Insights from the Critical Care Cardiology Trials Network (CCCTN) (Keane, ACC 2022)
Cardiac Surgical Therapy in the Contemporary CICU-Implications for the Heart Team, from CCCTN (Metkus, ACC 2022)
Targeted Proteomic Profiling of Cardiogenic Shock in the Cardiac Intensive Care Unit-An Analysis from the CCCTN (Lopes, ACC 2022)
Circulating Biomarker Patterns in Patients with Vasodilatory Cardiogenic Shock in the Cardiac Intensive Care Unit-Analysis from the CCCTN Registry (Senman, ACC 2022)
Interhospital Differences in the Use of Critical Care Therapies in CICUs and Its Association With In-Hospital Mortality-Insights from CCCTN (Donnelly, AHA 2022)
End-Organ Dysfunction Differs in Patients with Heart Failure-Related vs. Acute-Myocardial Infarction-Related Cardiogenic Shock (Varshney, AHA 2022)
Prognostic Significance of Hemodynamic Parameters in Patients with Cardiogenic Shock (Berg, ACC 2023)
Differences in Heart Failure-Related Cardiogenic Shock Between Ischemic and Non-Ischemic Cardiomyopathy: Data from The Critical Care Cardiology Network Registry (Feinman, ACC 2023)
Acute Kidney Injury and Outcomes in the Cardiac Intensive Care Unit: Insights from The Critical Care Cardiology Trials Network (Singam, ACC 2023)
Pre-shock and Normotensive Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry (Patel, ESC 2023)
Characteristics and Outcomes of Patients with Clinically Significant Valvular Heart Disease (Carnicelli, AHA 2023)
Association of Hemoglobin with In-Hospital Mortality in Patients Admitted to the Cardiac Intensive Care Unit Data from the CCCTN Registry (Chow, AHA 2023)
MICU Overflow Patients in the Cardiac Intensive Care Unit – Insights from the Critical Care Cardiology Trials Network Registry (Isath, AHA 2023)
Modes of In-Hospital Death In Patients with Cardiogenic Shock – An Analysis from the Critical Care Cardiology Trials Network (Singal, AHA 2023)
Early Evolution of SCAI Shock Stage and In-Hospital Mortality in a CICU Population from the Critical Care Cardiology Trials Network (CCCTN) (Skove, AHA 2023)
Use Of Palliative Care Services In Patients With Cardiogenic Shock: Insights From The Critical Care Cardiology Trials Network (CCCTN) Registry (McClintick, ACC 2024)
Early Changes In Aggregate Vasoactive Support And Mortality In Cardiogenic Shock: Insights From The Critical Care Cardiology Trials Network Registry (Patel, ACC 2024)
Cardiogenic Shock Epidemiology In Cardiac Intensive Care Units (CICUS) Using The Framework Of The Shock Academic Research Consortium (SHARC) Consensus Definitions (Berg, ACC 2024)
Trends in Temperature Control after Cardiac Arrest in Cardiac Intensive Care Units-An Analysis from the Critical Care Cardiology Trials Network Registry (Ariss, AHA 2024)
Variation in Vasoactive Treatments for Cardiogenic Shock-Insights from the Critical Care Cardiology Trials Network (CCCTN) (Hamilton, AHA 2024)
Characterization of Isolated Right Ventricular Congestion in Cardiogenic Shock (Kaur, AHA 2024)
Association between Pressure-Adjusted Heart Rate and Mortality in Cardiogenic Shock (Ginder, AHA 2024)
Recidivism in the Cardiac Intensive Care Unit-Insights from the Multinational Critical Care Cardiology Trials Network (Katz, AHA 2024)
Early transfer to an advanced heart failure center is associated with improved outcomes (Ungemach, ACC 2025)
Polygenic Risk Score Associated with Kidney Disease Progression in Patients with Cardiometabolic Disease (Park, AHA 2025)
Temporary MCS and Cardiogenic Shock-Characterizing Complications in Modern Practice (Kochar, AHA 2025)
Biomarkers in Cardiac Arrest-An Analysis from the Critical Care Cardiology Trials Network (S. Morrow, AHA 2025)