OCEAN(a)-DOSE -TIMI 67

A study to evaluate the efficacy, safety, and tolerability of Olpasiran (AMG890, a small interfering RNA) in subjects with elevated lipoprotein(a).

MAIN RESULTS:
Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

N Engl J Med  2022 Nov 17;387(20):1855-1864.

PRESENTATIONS

Reduction of Lipoprotein(a) With Small Interfering RNA – Results of the OCEAN(a)-DOSE (TIMI 67) Trial (O’Donoghue, AHA 2022)
Association of Baseline Lipoprotein(a) and Percentage of Lipoprotein(a) Lowering with Olpasiran (O’Donoghue, ACC 2023)
RNA Inhibition of Lipoprotein(a) with Olpasiran: Effects on Oxidized Phospholipids and Primary Results of the OCEAN(a)-DOSE (TIMI 67) Off-Treatment Extension Period (O’Donoghue, ESC 2023)
Intraindividual Variability in Serial Lipoprotein(a) Concentrations among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial (Gaba, AHA 2023)
Efficacy of Olpasiran by Apolipoprotein(a) Isoform-Size-Insights from the OCEAN(a)-DOSE Trial (Monguillon, AHA 2025)

OTHER PUBLICATIONS

Study Design and Rationale for the OCEAN(a)-DOSE (Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction-DOSE Finding Study) Trial. Am Heart J. 2022 May 16;251:61-69.

The Off-Treatment Effects of Olpasiran on Lipoprotein(a) Lowering: OCEAN(a)-DOSE Extension Period Results. J Am Coll Cardiol. 2024 Aug 27;84(9):790-797.

Olpasiran lowering of lipoprotein(a) according to baseline levels: insights from the OCEAN(a)-DOSE study.Eur Heart J. 2025 Mar 24;46(12):1162-1164.

Intraindividual Variability in Serial Lipoprotein(a) Concentrations Among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial. J Am Coll Cardiol. 2025 Feb 11;85(5):550-553.

Olpasiran, Oxidized Phospholipids, and Systemic Inflammatory Biomarkers: Results From the OCEAN(a)-DOSE Trial. JAMA Cardiol. 2025 May 1;10(5):482-486.

Small-Interfering RNA Olpasiran and Apolipoprotein B Particles. JAMA Cardiol. 2025 Nov 5:e254105. doi: 10.1001/jamacardio.2025.4105.

OCEAN(a)-DOSE on ClinicalTrials.gov

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