FOURIER Open Label Extension

FOURIER OLE_Study Schema

MAIN RESULTS:
Long-Term Evolocumab in Patients with Established Atherosclerotic Cardiovascular Disease
OLE

Circulation. 2022;146:1109–1119.

MAIN RESULTS PRESENTATIONS

FOURIER Open Label Extension Primary Results (O’Donoghue, ESC 2022)

PRESENTATIONS

Association Between Achieved LDL-Cholesterol and Long-term Cardiovascular and Safety Outcomes – An Analysis of the FOURIER and FOURIER-OLE Studies (Gaba, AHA 2022)
Reduction in Total CV Events with the PCSK9 Inhibitor Evolocumab in Patients with Cardiovascular Disease in the Combined FOURIER and FOURIER OLE Studies (Murphy, ACC 2023)
Long-term PCSK9 Inhibition with Evolocumab and Aortic Stenosis Events (Gaba, TCT 2023)
Association Between Achieved LDL-Cholesterol Levels and Long-term Cardiovascular and Safety Outcomes-An Analysis of FOURIER-OLE (Gaba, AHA 2023)
Long-Term Efficacy of Evolocumab in Patients with and without Multi-Vessel Disease (McClintick, AHA 2023)
Long-Term Neurocognitive Safety of LDL-C Lowering with Evolocumab-Open-Label Extension Data from FOURIER (Zimerman, AHA 2023)
Long-Term Evolocumab in Elderly Patients With Established Atherosclerotic Cardiovascular Disease – An Analysis from FOURIER and FOURIER-OLE (Al Said, ACC 2024)
Early Initiation of Evolocumab and Arterial Aneurysm Events in FOURIER & FOURIER-OLE (Gaba, AHA 2024)
Evolocumab and complex coronary revascularization during 8-year follow-up-Analysis from the FOURIER and FOURIER OLE trials (Haller, ACC 2025)
Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke (Monguillon, AHA 2025)

PUBLICATIONS

Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE. Circulation. 2023 Apr 18;147(16):1192-1203.

Response by O’Donoghue et al to Letter Regarding Article, “Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease”. Circulation. 2023 Apr 18;147(16):1258-1259.

Long-Term Efficacy of Evolocumab in Patients With or Without Multivessel Coronary Disease. J Am Coll Cardiol. 2024 Feb 13;83(6):652-664.

Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab. NEJM Evid. 2025 Jan;4(1):EVIDoa2400112.

Long-Term Lipid Lowering With Evolocumab in Older Individuals. J Am Coll Cardiol. 2025 Feb 11;85(5):504-512.

Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. Circulation. 2025 Nov 3. doi: 10.1161/CIRCULATIONAHA.125.077549.

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