IMPROVE-IT (TIMI 40) determined whether the addition of ezetimibe to statin therapy, using ezetimibe/simvastatin, improves cardiovascular outcomes compared with simvastatin monotherapy in patients after ACS. In addition, the difference in achieved LDL-C levels between the groups provided data on whether the target for LDL-C lowering should be reduced further.


Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
IMPROVE-IT TIMI 40N Engl J Med. 2015 Jun 18;372(25):2387-97.


Biomarkers (Qamar, AHA 2017) Association of Genetic Risk Score with Risk of Recurrent Coronary Events in IMPROVE-IT (Ruff, AHA 2018)
Ezetimibe Consistently Reduces LDL-C with Little Interindividual Variability in 14,970 Patients Post-ACS (Patel, AHA 2021)
Risk of Major Adverse Limb Events with Ezetimibe versus Placebo in Addition to Statin Therapy-Insights from the IMPROVE IT Trial (Bonaca, ESC 2023)


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