PIONEER-HF (TIMI 62)

PIONEER-HF was a multicenter, randomized, double-blind, double dummy, parallel group, active-controlled 8-week study to evaluate the effect of sacubitril and valsartan (LCZ696) versus enalapril on changes in NT-proBNP and safety and tolerability of in-hospital initiation of LCZ696 compared to enalapril in HFrEF patients who have been stabilized following hospitalization for acute decompensated heart failure (ADHF).

PIONEER-HF on ClinicalTrials.gov

PRESENTATIONS

Safety and Efficacy of Sacubitril/Valsartan by Dose Level in Patients Hospitalized with Acute Heart Failure (Morrow ESC 2019)
PIONEER High-risk Subgroups (Berg AHA 2019)

PUBLICATIONS

Angiotensin-Neprilysin Inhibition in Black Americans: Data From the PIONEER-HF Trial

Angiotensin Receptor-Neprilysin Inhibition Based on History of Heart Failure and Use of Renin-Angiotensin System Antagonists

Efficacy and Safety of Sacubitril/Valsartan by Dose Level Achieved in the PIONEER-HF Trial

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure: Secondary Analysis of the Open-label Extension of the PIONEER-HF Trial

The Association Between Congestion and Outcomes for Patients Treated With Sacubitril-Valsartan Compared to Enalapril in the PIONEER-HF Trial

Efficacy and Safety of Sacubitril/Valsartan in Acute Decompensated Heart Failure in High-Risk Patients in the PIONEER-HF Trial

Rationale and design of the comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode (PIONEER-HF) trial

Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

Clinical Outcomes in Patients With Acute Decompensated Heart Failure Randomly Assigned to Sacubitril/Valsartan or Enalapril in the PIONEER-HF Trial

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