PRINCIPLE-TIMI 44 compared prasugrel versus higher loading and maintenance doses of clopidogrel for inhibiting platelet aggregation in patients undergoing elective percutaneous intervention.
Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial
Circulation. 2007 Dec 18;116(25):2923-32.
Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. Thromb Haemost. 2011 Aug;106(2):219-26.