TIMI 1

TIMI 1 compared the efficacy of tissue plasminogen activator and streptokinase for reperfusion of the infarct-related artery in ST elevation myocardial infarction.

MAIN RESULTS:
The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I Findings.
TIMI 1
N Engl J Med. 1985 Apr 4;312(14):932-6.

PUBLICATIONS

High dose intravenous streptokinase for acute myocardial infarction: preliminary results of a multicenter trial. J Am Coll Cardiol. 1985 Nov;6(5):957-62.

Intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction: a report from the NHLBI thrombolysis in myocardial infarction trial. Circulation. 1986 Feb;73(2):338-46.

Comparison of monoplane and biplane assessment of regional left ventricular wall motion after thrombolytic therapy for acute myocardial infarction. Am J Cardiol. 1987 Apr 1;59(8):793-7.

The effect of intravenous thrombolytic therapy on left ventricular function: a report on tissue-type plasminogen activator and streptokinase from the Thrombolysis in Myocardial Infarction (TIMI Phase I) trial. Circulation. 1987 Apr;75(4):817-29.

Quantitation of fragment X formation during thrombolytic therapy with streptokinase and tissue plasminogen activator. J Clin Invest. 1987 Jun;79(6):1642-7.

Peak creatine kinase as a measure of effectiveness of thrombolytic therapy in acute myocardial infarction. Am J Cardiol. 1987 Jun 1;59(15):1234-8.

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation. 1987 Jul;76(1):142-54.

Thrombolysis in myocardial infarction (TIMI): comparative studies of coronary reperfusion and systemic fibrinogenolysis with two forms of recombinant tissue-type plasminogen activator. J Am Coll Cardiol. 1987 Sep;10(3):479-90.

Patient recruitment experience in the Thrombolysis in Myocardial Infarction Trial. Control Clin Trials. 1987 Dec;8(4 Suppl):86S-93S.

Thrombolysis in Myocardial Infarction (TIMI) Trial–phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol. 1988 Jan;11(1):1-11.

Impact of thrombolytic therapy on left ventricular mural thrombi in acute myocardial infarction. Am J Cardiol. 1988 Aug 1;62(4):310-1.

Six- and twelve-month follow-up of the phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Am J Cardiol. 1988 Aug 1;62(4):179-85.

Characterization in vivo of the fibrin specificity of activators of the fibrinolytic system. Circulation. 1988 Sep;78(3):592-7.

Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. J Am Coll Cardiol. 1989 Apr;13(5):998-1005.

A physiologically based model of creatine kinase-MB release in reperfusion of acute myocardial infarction. Am J Cardiol. 1989 Jul 1;64(1):11-5.

The use of tissue-type plasminogen activator for acute myocardial infarction in the elderly: results from thrombolysis in myocardial infarction Phase I, open label studies and the Thrombolysis in Myocardial Infarction Phase II pilot study. J Am Coll Cardiol. 1989 Nov 1;14(5):1159-65.

Cardiac morphologic findings in patients with acute myocardial infarction treated with recombinant tissue plasminogen activator. Am J Cardiol. 1990 Apr 15;65(15):953-61.

Comparison of coronary and myocardial morphologic findings in patients with and without thrombolytic therapy during fatal first acute myocardial infarction. Am J Cardiol. 1990 Oct 15;66(12):904-9.

The consent process in the Thrombolysis in Myocardial Infarction (TIMI–phase I) trial. Clin Res. 1991 Feb;39(1):13-7.

Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. Circulation. 1991 Mar;83(3):739-46.

The rt-PA versus streptokinase. Controversy–II. J Am Coll Cardiol. 1992 Apr;19(5):1116-9.

Mitral regurgitation in early myocardial infarction. Incidence, clinical detection, and prognostic implications. Ann Intern Med. 1992 Jul 1;117(1):10-7.

Effect of thrombolysis on acute mitral regurgitation during evolving myocardial infarction. Experience from the Thrombolysis in Myocardial Infarction (TIMI) Trial. J Am Coll Cardiol. 1993 Sep;22(3):714-9.

Value of rescue percutaneous transluminal coronary angioplasty following unsuccessful thrombolytic therapy in patients with acute myocardial infarction. Thrombolysis in Myocardial Infarction Investigators. Am J Cardiol. 1995 Dec 1;76(16):1108-11.

Trends in the use of pharmacotherapies for acute myocardial infarction among physicians who design and/or implement randomized trials versus physicians in routine clinical practice: the MILIS-TIMI experience. Multicenter Investigation on Limitation of Infarct Size. Thrombolysis in Myocardial Infarction. Am Heart J. 1999 Jan;137(1):79-92.

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