TIMI 4 compared the efficacy of front loaded tPA vs. APSAC vs. the combination of reduced dose tPA and APSAC for treatment of patients presenting within 6 hours of onset of ST elevation myocardial infarction.


TIMI 4 Slides


An approach to evaluating thrombolytic therapy in acute myocardial infarction. The ‘unsatisfactory outcome’ end point

Use of composite endpoints in thrombolysis trials of acute myocardial infarction

Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 4 trial

Use of a standardized heparin nomogram to achieve therapeutic anticoagulation after thrombolytic therapy in myocardial infarction. TIMI 4 investigators. Thrombolysis in Myocardial Infarction

Angiographic predictors of reocclusion after thrombolysis: results from the Thrombolysis in Myocardial Infarction (TIMI) 4 trial

Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning?

How do smokers differ from nonsmokers in their response to thrombolysis? (the TIMI-4 trial)

Thrombolytic Therapy for Acute Myocardial Infarction in Patients with Prior Coronary Bypass Surgery: Results from the Thrombolysis in Myocardial Infarction (TIMI) 4 Trial

Distortion of the terminal portion of the QRS on the admission electrocardiogram in acute myocardial infarction and correlation with infarct size and long-term prognosis (Thrombolysis in Myocardial Infarction 4 Trial)

TIMI frame count: a quantitative method of assessing coronary artery flow

Prospective validation of a composite end point in thrombolytic trials of acute myocardial infarction (TIMI 4 and 5). Thrombosis In Myocardial Infarction

Rescue angioplasty in the thrombolysis in myocardial infarction (TIMI) 4 trial

Relation between injections before 90-minute angiography and coronary patency: results of the thrombolysis in myocardial infarction 4 trial

Protection Conferred by Preinfarct Angina is Manifest in the Aged Heart: Evidence from the TIMI 4 Trial

Relationship between TIMI frame count and clinical outcomes after thrombolytic administration.

Combination therapy with abciximab reduces angiographically evident thrombus in acute myocardial infarction: a TIMI 14 substudy

Seasonal variation of myocardial infarct size

Ischemic preconditioning: implications for the geriatric heart

Comparison of acute myocardial infarct size in patients > or =65 years versus < 65 years in the prethrombolytic period versus the thrombolytic period

Evaluation of the association of proximal coronary culprit artery lesion location with clinical outcomes in acute myocardial infarction

Sequential risk stratification using TIMI risk score and TIMI flow grade among patients treated with fibrinolytic therapy for ST-segment elevation acute myocardial infarction






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