TIMI 5 evaluated the safety and efficacy of several doses of hirudin vs. unfractionated heparin in combination with front-loaded tPA for the treatment of patients presenting with ST elevation myocardial infarction.
Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction
A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial