TIMI 5 evaluated the safety and efficacy of several doses of hirudin vs. unfractionated heparin in combination with front-loaded tPA for the treatment of patients presenting with ST elevation myocardial infarction.
A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial
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Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction. Am J Cardiol. 1996 Sep 1;78(5):503-10.