TIMI 9A compared the safety and efficacy of intravenous hirudin to unfractionated heparin as adjunctive therapy to fibrinolysis and aspirin among patients presenting with ST elevation myocardial infarction.
Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial
Circulation. 1994 Oct;90(4):1624-30.