TIMI 9B compared the efficacy of a lower dose of intravenous hirudin to unfractionated heparin as adjunctive therapy to fibrinolysis and aspirin among patients presenting with ST elevation myocardial infarction.
MAIN RESULTS:
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial

Circulation. 1996 Sep 1;94(5):911-21.
OTHER PUBLICATIONS
Hirudin: Its Biology and Clinical Use. J Thromb Thrombolysis. 1994;1(1):7-16.
Hirudin in Acute Myocardial Infarction. J Thromb Thrombolysis. 1995;1(3):259-267.
Trials and tribulations of thrombin inhibition. Eur Heart J. 1996 Jul;17(7):971-3.
Another chapter of the antithrombin story has been written. Eur Heart J. 1997 Sep;18(9):1365-7.