TIMI 9B compared the efficacy of a lower dose of intravenous hirudin to unfractionated heparin as adjunctive therapy to fibrinolysis and aspirin among patients presenting with ST elevation myocardial infarction.
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial
Circulation. 1996 Sep 1;94(5):911-21.
Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study. J Am Coll Cardiol. 1999 Feb;33(2):479-87.