TIMI 9B

TIMI 9B compared the efficacy of a lower dose of intravenous hirudin to unfractionated heparin as adjunctive therapy to fibrinolysis and aspirin among patients presenting with ST elevation myocardial infarction.

MAIN RESULTS:
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial

Circulation. 1996 Sep 1;94(5):911-21.

OTHER PUBLICATIONS

Hirudin: Its Biology and Clinical Use. J Thromb Thrombolysis. 1994;1(1):7-16.

Hirudin in Acute Myocardial Infarction. J Thromb Thrombolysis. 1995;1(3):259-267.

Hirudin: initial results in acute myocardial infarction, unstable angina and angioplasty. J Am Coll Cardiol. 1995 Jun;25(7 Suppl):30S-37S.

Trials and tribulations of thrombin inhibition. Eur Heart J. 1996 Jul;17(7):971-3.

Reexamination of the Thrombin Hypothesis: What We Have Learned from TIMI 9B and GUSTO IIb. J Thromb Thrombolysis. 1997;4(3/4):321-323.

Another chapter of the antithrombin story has been written. Eur Heart J. 1997 Sep;18(9):1365-7.

Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B. Circulation. 1998 Mar 24;97(11):1042-5.

Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study. J Am Coll Cardiol. 1999 Feb;33(2):479-87.

Lower-dose heparin with fibrinolysis is associated with lower rates of intracranial hemorrhage. Am Heart J. 2001 May;141(5):742-50.

Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients’ data.  Lancet. 2002 Jan 26;359(9303):294-302.

Poor outcomes after fibrinolytic therapy for ST-segment elevation myocardial infarction: impact of age (a meta-analysis of a decade of trials). J Thromb Thrombolysis. 2006 Apr;21(2):119-29.