LAPLACE-TIMI 57 assessed whether 12 weeks of therapy with a novel injectable monoclonal antibody against PCSK9, given on a background of statin therapy, will be safe and to what degree it will reduce LDL-cholesterol in hypercholesterolemic subjects.
MAIN RESULTS:
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study

Lancet. 2012 Dec 8;380(9858):2007-17
PRESENTATIONS
LAPLACE-TIMI 57 Primary Results (AHA 2012)
TIMI 57 Slides