FOURIER (TIMI 59) was a double-blind, randomized, placebo-controlled, multicenter study assessing the Impact of additional LDL-cholesterol reduction on major cardiovascular events when AMG 145 is used in combination with statin therapy in patients with clinically evident cardiovascular disease. EBBINGHAUS was a cognitive study of patients enrolled in the FOURIER trial.
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
N Engl J Med. 2017 May 4;376(18):1713-1722.
MAIN RESULTS PRESENTATIONS
Maximum Intensity Statin (Sabatine, NLA 2017)
Achieved LDL-C (Giugliano, ESC 2017)
Stroke (Pederson, ESC 2017)
Diabetes (Sabatine, EASD 2017)
PAD (Bonaca, AHA 2017)
MI Subgroup (Sabatine, AHA 2017)
Total Events (Murphy, AHA 2017)
MI Size and Type (Wiviott, AHA 2017)
Risk Score (Bohula, AHA 2017)
Variability in Evolocumab (Qamar, ACC 2018)
Inflammatory and Cholestrol Risk (Bohula, ACC 2018)
Martin Hopkins LDL-C (Martin, NLA 2018)
Lp(a) in FOURIER (O’Donoghue, EAS 2018)
Age and Sex (Sever, ESC 2018)
FOURIER Cognition Poster (Gencer, AHA 2019)
FOURIER Genetics (Marston, AHA 2019)
FOURIER Recent MI Poster (Gencer, AHA 2019)
Performance Of A Novel Genetic Risk Score To Identify Risk Of VTE In Patients With Cardiometabolic Disease (Marston, ACC 2020)
PCSK9 Inhibition And Aortic Stenosis In The FOURIER Trial (Bergmark, ACC 2020)
Efficacy of Lowering Low-Density Lipoprotein Cholesterol in Older Patients (Gencer, AHA 2020)
Relationship Between Baseline LDL-C and %LDL-C Reduction with Evolocumab in the FOURIER Trial (Marcusa, AHA 2020)
Reduction with Evolocumab in Complex Coronary Revascularization (Oyama, AHA 2020)
A Novel Genetic Risk Score Predicts Ischemic Stroke in Patients with Cardiometabolic Disease (Patel, AHA 2020)
Cardiovascular Outcomes in Patients with Established Atherosclerosis and LDLR Loss of Function (Marston, AHA 2020)
Combining High-Sensitivity Troponin with the AHA/ACC Cholesterol Guidelines To Guide Evolocumab Therapy (Marston, AHA 2020)
Effects of Evolocumab in Patients with Prior Percutaneous Coronary Intervention (Furtado, AHA 2020)
Biomarker prediction of major coronary events and complex revascularization procedures in patients with stable atherosclerosis (Fagundes, Jr., ACC 2021)
Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial. Clin Cardiol. 2017 Feb;40(2):59-65.
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial. Lancet. 2017 Oct 28;390(10106):1962-1971.
Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial. Lancet Diabetes Endocrinol. 2017 Dec;5(12):941-950.
Clinical Efficacy and Safety of Evolocumab in High-Risk Patients Receiving a Statin: Secondary Analysis of Patients With Low LDL Cholesterol Levels and in Those Already Receiving a Maximal-Potency Statin in a Randomized Clinical Trial. JAMA Cardiol. 2017 Dec 1;2(12):1385-1391.
Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients With Peripheral Artery Disease: Insights From the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk). Circulation. 2018 Jan 23;137(4):338-350.
Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation: Insights From the FOURIER Trial. JAMA Cardiol. 2018 Aug 1;3(8):749-753.
Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis. Stroke. 2020 May;51(5):1546-1554.
Efficacy and Safety of PCSK9 Inhibition With Evolocumab in Reducing Cardiovascular Events in Patients With Metabolic Syndrome Receiving Statin Therapy: Secondary Analysis From the FOURIER Randomized Clinical Trial. JAMA Cardiol. 2021 Feb 1;6(2):139-147.
Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials. Lancet. Volume 396, Issue 10263, P1637-1643, November 21, 2020.
Association of Baseline Low-Density Lipoprotein Cholesterol and Percentage Low-Density Lipoprotein Cholesterol Reduction With Statins, Ezetimibe, and PCSK9 Inhibition. JAMA Cardiol. 2020 Nov 13;6(5):1-5.
Efficacy and Safety of Long-Term Evolocumab Use Among Asian Subjects – A Subgroup Analysis of the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) Trial. Circ J. 2021 May 12. doi: 10.1253/circj.CJ-20-1051.